Optimal Cerebral Perfusion PressureCPPopt research website

Welcome to the CPPopt website

Cerebral perfusion pressure (CPP) management based on cerebral autoregulation indices, such as cerebrovascular pressure reactivity (PRx) has the potential to provide a dynamic and personalised treatment target and subsequently improve patient outcomes. In literature, the term Optimal Cerebral Perfusion Pressure (CPPopt) was used to refer to this ‘individual’ treatment target as an example of autoregulation guided management.

Several successful research work has been performed to investigate retrospectively the patient’s outcome related to the deviation from CPPopt. Research fields include traumatic brain injury, intracranial hemorrhage, subarachnoid hemorrhage and monitoring of children/neonates.

Our website has the aim to inform researchers about new findings regarding CPPopt, give background  information, research projects and it is an ability  to share new ideas.

Please subscribe to the CPPopt newsletter (at the bottom of the webpage) if you want to be updated automatically.

On behalf of the (international) CPPopt team,

Marcel Aries and Jeanette Tas

COGiTATE CPPopt Feasibility Study Inclusion 2018-2021

The plan is to enroll a total of 60 patients among three centers.

News and Recent Publications

 Articles about CPPopt

Donnelly J, Czosnyka M, Adams H, et al. Individualizing threshold of cerebral perfusion pressure using estimated limits of autoregulation. crit care med. 2017; 45:1464-1471.

Liu X, Donnelly J, Czosnyka M, et al. Cerebrovascular pressure reactivity monitoring using wavelet analysis in traumatic brain injury patients : A retrospective study, 2017; 1–19. http://doi.org/10.1371/journal.pmed.1002348.

Needham E, McFadyen C, Newcombe V et al. Cerebral Perfusion Pressure Targets Individualized to Pressure-Reactivity Index in Moderate toSevere Traumatic Brain Injury: A Systematic Review. J Neurotrauma. 2016 June; doi:10.1089/neu.2016.4450. 

Depreitere B, Güiza F, Van den Berghe G, Schuhmann MU et al. Can Optimal Cerebral Perfusion  Pressure in Patients with Severe Traumatic Brain Injury Be Calculated Based on Minute -by-Minute Data monitoring? Acta Neurochir. Suppl. 2016;122:245-8.

 Articles about Cerebral Autoregulation

Adams H, Donnelly J, Czosnyka M, et al. Temporal profile of intracranial pressure and cerebrovascular reactivity in severe traumatic brain injury and association with fatal outcome: an observational study. plos med. 2017 jul 25;14(7):e1002353.

Kooi EMW, Verhagen EA, Elting JWJ, et aL. Measuring cerebrovascular autoregulation in preterm infants using near-infrared spectroscopy : an overview of the literature. Expert Review of Neurotherapeutics. June 2017; 0(0), 1–18. http://doi.org/10.1080/14737175.2017.1346472.

Guiza F,  Meyfroidt G, Piper I, et al. Cerebral perfusion pressure insults and associations with outcome in adult traumatic brain injury. Journal of Neurotrauma. April 2017, ahead of print. doi:10.1089/neu.2016.4807.


 Books and Theses

 🔗 Prabhakar H, Neuromonitoring Techniques: Quick Guide for Clinicians and Residents 1st Edition (2017), London (UK), Academic press.

🔗 Aries, M.J.H. 2012. Cerebral Hemodynamics in Stroke and Traumatic Brain Injury, PhD thesis,
University of Groningen.

🔗 Liu, X.2017. Optimization of the assessment of cerebral autoregulation in neurocritical care, PhD thesis,
University of Cambridge.

🔗 Donnelley, J. 2017. Intracranial Monitoring after Severe Traumatic Brain Injury, PhD thesis,
University of Cambridge.



Symposium logo "ICP 2016"
Logo MIT
Summary of Boston’s 1st CPPopt symposium (2016)


Autoregulation monitoring course (TBI) Hong Kong (October 2017). 

Lectures by Peter Smielewski, PhD


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