Welcome to the CPPopt website
Cerebral perfusion pressure (CPP) management based on cerebral autoregulation indices, such as cerebrovascular pressure reactivity (PRx) has the potential to provide a dynamic and personalised treatment target and subsequently improve patient outcomes. In literature, the term Optimal Cerebral Perfusion Pressure (CPPopt) was used to refer to this ‘individual’ treatment target as an example of autoregulation guided management.
Several successful research work has been performed to investigate retrospectively the patient’s outcome related to the deviation from CPPopt. Research fields include traumatic brain injury, intracranial hemorrhage, subarachnoid hemorrhage and monitoring of children/neonates.
Our website has the aim to inform researchers about new findings regarding CPPopt, give background information, research projects and it is an ability to share new ideas.
Please subscribe to the CPPopt newsletter (at the bottom of the webpage) if you want to be updated automatically.
On behalf of the (international) CPPopt team,
Marcel Aries and Jeanette Tas
COGiTATE CPPopt Feasibility Study Inclusion 2018-2021
The plan is to enroll a total of 60 patients among three centers.
News and Recent Publications
Articles about CPPopt
Donnelly J, Czosnyka M, Adams H, et al. Individualizing threshold of cerebral perfusion pressure using estimated limits of autoregulation. crit care med. 2017; 45:1464-1471.
Liu X, Donnelly J, Czosnyka M, et al. Cerebrovascular pressure reactivity monitoring using wavelet analysis in traumatic brain injury patients : A retrospective study, 2017; 1–19. http://doi.org/10.1371/journal.pmed.1002348.
Needham E, McFadyen C, Newcombe V et al. Cerebral Perfusion Pressure Targets Individualized to Pressure-Reactivity Index in Moderate toSevere Traumatic Brain Injury: A Systematic Review. J Neurotrauma. 2016 June; doi:10.1089/neu.2016.4450.
Depreitere B, Güiza F, Van den Berghe G, Schuhmann MU et al. Can Optimal Cerebral Perfusion Pressure in Patients with Severe Traumatic Brain Injury Be Calculated Based on Minute -by-Minute Data monitoring? Acta Neurochir. Suppl. 2016;122:245-8.
Articles about Cerebral Autoregulation
Adams H, Donnelly J, Czosnyka M, et al. Temporal profile of intracranial pressure and cerebrovascular reactivity in severe traumatic brain injury and association with fatal outcome: an observational study. plos med. 2017 jul 25;14(7):e1002353.
Kooi EMW, Verhagen EA, Elting JWJ, et aL. Measuring cerebrovascular autoregulation in preterm infants using near-infrared spectroscopy : an overview of the literature. Expert Review of Neurotherapeutics. June 2017; 0(0), 1–18. http://doi.org/10.1080/14737175.2017.1346472.
Guiza F, Meyfroidt G, Piper I, et al. Cerebral perfusion pressure insults and associations with outcome in adult traumatic brain injury. Journal of Neurotrauma. April 2017, ahead of print. doi:10.1089/neu.2016.4807.
Books and Theses
Lectures by Peter Smielewski, PhD