Welcome to the CPPopt website

Cerebral perfusion pressure (CPP) management based on cerebral autoregulation indices, such as cerebrovascular pressure reactivity (PRx) has the potential to provide a dynamic and personalised treatment target and subsequently improve patient outcomes. In literature, the term Optimal Cerebral Perfusion Pressure (CPPopt) was used to refer to this ‘individual’ treatment target as an example of autoregulation guided management.

Several successful research work has been performed to investigate retrospectively the patient’s outcome related to the deviation from CPPopt. Research fields include traumatic brain injury, intracranial hemorrhage, subarachnoid hemorrhage and monitoring of children/neonates.

Our website has the aim to inform researchers about new findings regarding CPPopt, give background  information, research projects and it is an ability  to share new ideas.

Please subscribe to the CPPopt newsletter (at the bottom of the webpage) if you want to be updated automatically.

On behalf of the (international) CPPopt team,

Marcel Aries and Jeanette Tas

News and Recent Publications

Articles about CPPopt

Beqiri, E., Ercole, A., Aries, et al. Towards autoregulation-oriented management after traumatic brain injury: increasing the reliability and stability of the CPPopt algorithm. Journal of clinical monitoring and computing, 2023.

Tas, J., Beqiri, E., van Kaam, R. C., et al. Targeting Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGiTATE): A Feasibility Randomized Controlled Clinical Trial. Journal of neurotrauma, 2021.

Tas, J, Bequiri, E, van Kaam, CR, et al. An Update on the COGiTATE Phase II Study: Feasibility and Safety of Targeting an Optimal Cerebral Perfusion Pressure as a Patient-Tailored Therapy in Severe Traumatic Brain Injury. Acta Neurochir Suppl. 2021.

Beqiri, E., Smielewski, P., Robba, Cet al. (2019). Feasibility of individualised severe traumatic brain injury management using an automated assessment of optimal cerebral perfusion pressure: the COGiTATE phase II study protocol. BMJ Open, Sep 2019.

Article about Cerebral Autoregulation

Claassen JAHR, Thijssen DHJ, Panerai RB, Faraci FM. Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation. Physiol Rev. 2021 Oct.

Books and PhD-thesis

Tas, J. (2023). Next generation neuromonitoring: multimodality, cerebral autoregulation and a refined outcome in severe traumatic brain injury. [Doctoral Thesis, Maastricht University]. Maastricht University. https://doi.org/10.26481/dis.20230424jt

Liu, X.2017. Optimization of the assessment of cerebral autoregulation in neurocritical care, PhD thesis, University of Cambridge.

Donnelley, J. 2017. Intracranial Monitoring after Severe Traumatic Brain Injury, PhD thesis, University of Cambridge.

Aries, M.J.H. 2012. Cerebral Hemodynamics in Stroke and Traumatic Brain Injury, PhD thesis,
University of Groningen.